Judson J. Wambold
It's refreshing to be a part of a team of consummate professionals who work tirelessly for their clients. Joined forces with Daymon Worldwide to greatly expand brand and retailer services in the U. For companies with multiple common share classes, market capitalization includes both classes. Shareholders like president of hedge fund Providence Capital, Herbert Denton … wanted three of the firms' directors to step down. Rodek … has hired one new director and is looking for another.
Overall, the exercise where the most significant improvements were observed is the bench press. The measurement of the dissociation between anabolic and androgenic effects among AAS is based largely on a simple although arguably unsophisticated and outdated model involving rat tissue bioassays.
The intracellular metabolism theory explains how and why remarkable dissociation between anabolic and androgenic effects can occur despite the fact that these effects are mediated through the same signaling receptor, and of course why dissociation is invariably incomplete.
An animal study found that two different kinds of androgen response elements could differentially respond to testosterone and DHT upon activation of the AR. Changes in endogenous testosterone levels may also contribute to differences in myotrophic—androgenic ratio between testosterone and synthetic AAS. Testosterone can be metabolized by aromatase into estradiol , and many other AAS can be metabolized into their corresponding estrogenic metabolites as well.
The major effect of estrogenicity is gynecomastia woman-like breasts. AAS are androstane or estrane steroids. As well as others such as 1-dehydrogenation e.
The most commonly employed human physiological specimen for detecting AAS usage is urine, although both blood and hair have been investigated for this purpose. The AAS, whether of endogenous or exogenous origin, are subject to extensive hepatic biotransformation by a variety of enzymatic pathways.
The primary urinary metabolites may be detectable for up to 30 days after the last use, depending on the specific agent, dose and route of administration. A number of the drugs have common metabolic pathways, and their excretion profiles may overlap those of the endogenous steroids, making interpretation of testing results a very significant challenge to the analytical chemist. Methods for detection of the substances or their excretion products in urine specimens usually involve gas chromatography—mass spectrometry or liquid chromatography-mass spectrometry.
The use of gonadal steroids pre-dates their identification and isolation. Medical use of testicle extract began in the late 19th century while its effects on strength were still being studied. In the s, it was already known that the testes contain a more powerful androgen than androstenone , and three groups of scientists, funded by competing pharmaceutical companies in the Netherlands, Germany, and Switzerland, raced to isolate it.
The chemical synthesis of testosterone was achieved in August that year, when Butenandt and G. Wettstein, announced a patent application in a paper "On the Artificial Preparation of the Testicular Hormone Testosterone Androstenoneol.
Clinical trials on humans, involving either oral doses of methyltestosterone or injections of testosterone propionate , began as early as Kennedy was administered steroids both before and during his presidency.
The development of muscle-building properties of testosterone was pursued in the s, in the Soviet Union and in Eastern Bloc countries such as East Germany, where steroid programs were used to enhance the performance of Olympic and other amateur weight lifters. In response to the success of Russian weightlifters, the U. The new steroid was approved for use in the U. It was most commonly administered to burn victims and the elderly.
The drug's off-label users were mostly bodybuilders and weight lifters. Although Ziegler prescribed only small doses to athletes, he soon discovered that those having abused Dianabol suffered from enlarged prostates and atrophied testes. Three major ideas governed modifications of testosterone into a multitude of AAS: Androgens were discovered in the s and were characterized as having effects described as androgenic i.
Although anabolic steroid was originally intended to specifically describe testosterone-derived steroids with a marked dissociation of anabolic and androgenic effect, it is applied today indiscriminately to all steroids with AR agonism-based anabolic effects regardless of their androgenic potency, including even non-synthetic steroids like testosterone itself.
The legal status of AAS varies from country to country: Unlawful distribution or possession with intent to distribute AAS as a first offense is punished by up to ten years in prison. Those guilty of buying or selling AAS in Canada can be imprisoned for up to 18 months. In Canada, researchers have concluded that steroid use among student athletes is extremely widespread.
A study conducted in by the Canadian Centre for Drug-Free Sport found that nearly 83, Canadians between the ages of 11 and 18 use steroids. AAS are readily available without a prescription in some countries such as Mexico and Thailand. The history of the U. The same act also introduced more stringent controls with higher criminal penalties for offenses involving the illegal distribution of AAS and human growth hormone. By the early s, after AAS were scheduled in the U. In the Controlled Substances Act, AAS are defined to be any drug or hormonal substance chemically and pharmacologically related to testosterone other than estrogens , progestins , and corticosteroids that promote muscle growth.
The act was amended by the Anabolic Steroid Control Act of , which added prohormones to the list of controlled substances , with effect from January 20, In the United Kingdom, AAS are classified as class C drugs for their illegal abuse potential, which puts them in the same class as benzodiazepines.
Part 1 drugs are subject to full import and export controls with possession being an offence without an appropriate prescription. There is no restriction on the possession when it is part of a medicinal product. Part 2 drugs require a Home Office licence for importation and export unless the substance is in the form of a medicinal product and is for self-administration by a person.
Many other countries have similar legislation prohibiting AAS in sports including Denmark,  France,  the Netherlands  and Sweden. United States federal law enforcement officials have expressed concern about AAS use by police officers. It's not that we set out to target cops, but when we're in the middle of an active investigation into steroids, there have been quite a few cases that have led back to police officers," says Lawrence Payne, a spokesman for the United States Drug Enforcement Administration.
Following the murder-suicide of Chris Benoit in , the Oversight and Government Reform Committee investigated steroid usage in the wrestling industry. The documents stated that 75 wrestlers—roughly 40 percent—had tested positive for drug use since , most commonly for steroids. AAS are frequently produced in pharmaceutical laboratories, but, in nations where stricter laws are present, they are also produced in small home-made underground laboratories, usually from raw substances imported from abroad.
As with most significant smuggling operations, organized crime is involved. In the late s, the worldwide trade in illicit AAS increased significantly, and authorities announced record captures on three continents. In , Finnish authorities announced a record seizure of A year later, the DEA seized In the first three months of , Australian customs reported a record seizures of AAS shipments. Illegal AAS are sometimes sold at gyms and competitions, and through the mail, but may also be obtained through pharmacists, veterinarians, and physicians.
AAS, alone and in combination with progestogens , have been studied as potential male hormonal contraceptives. From Wikipedia, the free encyclopedia. This article is about androgens as medications. For androgens as natural hormones, see Androgen. Ergogenic use of anabolic steroids. Use of performance-enhancing drugs in sport. Illegal trade in anabolic steroids. Pharmacy and Pharmacology portal. British Journal of Pharmacology. Houglum J, Harrelson GL, eds. Principles of Pharmacology for Athletic Trainers 2nd ed.
Int J Sports Med. Mini Rev Med Chem. Anabolic-androgenic steroid therapy in the treatment of chronic diseases". Clinics in Endocrinology and Metabolism. Pharmacology Application in Athletic Training. Clinical Guidelines for Prevention and Treatment. Royal College of Physicians.
Anabolic Steroids and the Athlete, 2d ed. Food and Drug Administration. Retrieved 21 June A systematic review and meta-analysis". Expert Opinion on Pharmacotherapy. Current Allergy and Asthma Reports. Clinics in Liver Disease. The named reference Llewellyn was invoked but never defined see the help page. Neidle 19 March Pharmacology and Therapeutics for Dentistry - E-Book. Do testosterone injections increase libido for elderly hypogonadal patients? Retrieved November 17, Retrieved December 5, Freter 30 July Perry's The Chemotherapy Source Book.
J Womens Health Larchmt. Results from four national surveys". Drug and Alcohol Dependence. Med Sci Sports Exerc. J Int Soc Sports Nutr. Journal of Health Psychology. Medicine and science in sports and exercise. Principles and Practice of Endocrinology and Metabolism. In Katzung, Bertram G. Applied modifications in the steroidal structure". Medical consequences of doping with anabolic androgenic steroids: Handb Exp Pharmacol Eur Rev Med Pharmacol Sci.
J Sci Med Sport. Annals of Internal Medicine. The Journal of Adolescent Health. The Journal of emergency medicine. Clin J Sport Med. University of California — San Francisco. Journal of Sports Science and Medicine. Archived PDF from the original on 20 June Lay summary — ScienceDaily October 30, A Looming Public Health Concern? Annals of Clinical Psychiatry. What the psychiatrist needs to know". Advances in Psychiatric Treatment. Br J Sports Med. Archived from the original on And Other Performance-enhancing Drugs.
Am J Public Health. Archived from the original on 10 July A Systematic Review and Meta-Analysis". J Acquir Immune Defic Syndr.
Retrieved 2 January Proceedings of the Society for Experimental Biology and Medicine. The New England Journal of Medicine. Penn Clinical Manual of Urology. Protective Effects of Tea on Human Health.
Therefore, it is possible that a selective androgen response element sequence may play a role in differential T vs. Although both testosterone and dihydrotestosterone activate the same androgen receptor, differences in the sequence of androgen response elements are responsible for differential regulation of these hormones Int J Mol Sci. Bilezikian; Dirk Vanderschueren 30 November The Effects of Gender on Skeletal Health. Kochakian 6 December Brocklehurst's Textbook of Geriatric Medicine and Gerontology.
Regulation of the secretion of GnRH, FSH, and LH occurs partially by the negative feedback of testosterone and estradiol at the level of the hypothalamo-pituitary. Estradiol has a much larger, inhibitory effect than testosterone, being fold more effective in suppressing LH secretion [57—61]. Androgens, estrogens and progestins exert a negative feedback effect on the secretion of GnRH and LH by their actions on the pituitary and the hypothalamus.
Most of the negative feedback effect of androgens is caused by their estrogenic metabolites produced by aromatization. Rittmaster et al, ; Kumar et al, a; Hayes et al, Travis 23 September Essentials of Strength Training and Conditioning 4th Edition. Foye's Principles of Medicinal Chemistry. Larry; De Groot, Leslie J. Handbook of Experimental Pharmacology. Disposition of Toxic Drugs and Chemicals in Man 8th ed.
On behalf of the ownership Lisa successfully negotiated the following: I came to Tactix to give my clients more. In commercial real estate information and service is key. Having followed the Tactix team for years, I was always impressed by the testimonials of their clients and the level of service they were able to provide.
The deals that Tactix successfully accomplished is unmatched by anyone else in the tristate market. I believed that my 30 years of commercial real estate experience including ownership, development and brokerage would be a unique perspective and an asset for Tactix to have. Martin Bond joined Tactix in after 20 years as a commercial real estate lawyer. Client he has worked with include:. As a real estate lawyer, most of my time was spent documenting complex transactions, protecting my clients from risk.
A small part of my practice — but the most satisfying by far — was structuring deals to help clients save money. When I had the chance to join Tactix, I jumped at the opportunity. I'd known the people at Tactix for many years, and knew them to be smart, well trained, ethical and hard working. Importantly, they seemed to be having a lot more fun than they'd had as lawyers, largely because they were adding tremendous value for their clients.
It also seemed to me that Tactix had created a better mousetrap. The firm operated much like a law firm, with a high degree of collaboration, a focus on client service, a relentless dedication to getting each client the best deal possible, and an insistence on being free of conflicts of interest. They couldn't have been more different from a traditional commercial real estate brokerage firms.
After I joined Tactix, I found that all of my perceptions were right. And I discovered for myself that putting money in a client's pocket is far more satisfying than anything I ever did as a lawyer. Rob Cellucci has a strong foundation in all facets of commercial real estate leasing and build-to-suit development. Prior to joining Tactix in , Rob worked in the Global Corporate Services division of an international brokerage firm.
Rob assisted corporate clients in the management of office, retail, and industrial transactions, ranging from 3, to , SF. In this role, Rob developed a high level of proficiency while managing each stage of the process, including corporate strategizing, market and financial analysis, site selection, and letter of intent and lease negotiations.
Over the course of his career, Rob has successfully managed over 2. Clients that Rob has had the opportunity to work extensively with include the following organizations among others:. James Madison University, B. Economic and Social Policy of the European Union. Before deciding to leave my relationship with a large, international brokerage firm, I thoroughly vetted several other global brokerage firms in the Philadelphia area. Frankly, something was missing. Some mentors of mine recommended that, before making a decision, I explore an opportunity with Tactix because of their strong reputation and unique business platform.
In an industry sometimes ridden with questionable salesmanship, I perceived Tactix to be a unique organization that strongly promoted the concept of honest and unbiased real estate advisory. Finally, I found that the strict tenant representation model, supported by a collaboration of professionals with storied financial and legal sagacity would allow me to provide my clients with the highest quality service. It was the right choice. Ryan Conner has been a broker with Tactix since His passion for all things real estate started during his days as a Special Projects Coordinator for the Riverfront Development Corporation of Delaware, a state chartered public corporation established to rehabilitate and revitalize Wilmington, Delaware's major waterway — the Christiana Riverfront.
Since joining Tactix he has worked on some of the most significant, exciting tenant representation projects in the region:. Ryan also remains connected to his roots in land development representing institutions and individuals in the disposition of land with development opportunity.
University of Delaware, B. When I decided to leave Preferred Unlimited over four years ago, I considered almost every national, full service brokerage firm in the region. But after meeting with the principals of Tactix the decision was an easy one.
The Tactix platform was different than any I had seen. No other firm offered a genuine tenant advocacy model staffed with real estate professionals not salespeople with deep legal and financial backgrounds and no other firm offered me regular, direct access to the owners of the firm.
Further, the values of the firm aligned with mine. I continue to be a staunch believer in our unique approach to real estate brokerage and look forward to contributing to the limitless potential of this company. Tim joined Tactix in , continuing a year career in commercial real estate. Throughout his career, he advised public companies, institutional owners and private companies in site selection, new leases, lease restructurings, development and financing.
When I started in the real estate industry over 25 years ago, each firm had its own database of information. It was a closely guarded secret of availabilities, market rates and sales prices. However, over the past several years, information has become commoditized.
It is easily accessible, and the various platforms that provide this information to the brokerage industry make it available equally to all. I selected Tactix for several reasons. They uncompromisingly work for the users of real estate. Their clients can be certain that there is no conflict of interest when they are at the negotiation table. Most of the members of Tactix have advanced degrees representing a range of interests from law to the advanced sciences.
It gives the members of the team the confidence that when walking into a meeting there is no real estate problem that may arise that cannot be solved for our clients. Scott Crumley has been a broker with Tactix since At Drinker, he was a member of the commercial real estate group where he specialized in complex leasing transactions and earned the distinction of being named a Pennsylvania Rising Star by Law and Politics magazine. In addition to leasing transactions, his legal experience included acquisitions, dispositions and financings of numerous commercial properties as well as the preparation negotiation of construction and design contracts.
Since joining Tactix he has worked on many significant, exciting tenant representation projects for clients including:. University of Richmond School of Law, J. During my time as a practicing lawyer I had professional interactions with many brokers and saw that the quality of those brokers varied widely, sometimes to the detriment of their clients.
My impressions of Tactix were quite different from other brokers—they consistently advocated for their clients with skill and professionalism and were instrumental in bringing transactions to a successful conclusion.
When I decided to make a career change to brokerage Tactix was the clear choice for me. After 8 years in financial sales and banking, Rick Freeth joined Tactix as an opportunity to grow with an industry as hot as Philadelphia. He is a huge proponent of the Philanthropic side of business, actively involving himself in community financial literacy and grassroots small business growth.
Great things happen to most people but a few times in life. Sometimes you find something you are good at, and sometimes you find something you do purely because you enjoy it; the team here has been fortunate enough to marry both.
The quality of the work and the reputation this team brings to the table speak for themselves. Leah joined the Tactix team in ; bringing with her over 15 years of real estate experience, across a variety of different service lines; including commercial leasing, project management, property management, and residential sales. Leah began her Real Estate career while still in high school; as a Receptionist and Office Administrator at a prominent Mainline residential firm.
Leah continued and expanded this position, for approximately five years, while attending Villanova University; as well as completing the education for her real estate salesperson license. Most recently she was the Operations Director at another tenant only representation firm. The Tactix team has earned an unsurpassed reputation for being ethical, conflict free, hardworking advocates for their clients.
This reputation, combined with a culture that is focused on doing good work, as opposed to pushing sales, is a breath of fresh air within the industry; and something that I am proud to have the opportunity to be a team member. Wayne Hunt joined Tactix in after 30 years of progressive institutional experience in commercial real estate as both a manager and practitioner with national firms.
University of Massachusetts, B. I previously worked with the principals of Tactix on many complex real estate transactions where I was on the other side representing the landlord. In all instances, I found them to be extremely well informed, very bright and unapologetic advocates for their client.
When the opportunity arose to join my former adversaries in a collaborative environment, where the interest of the client is paramount and the professionals have accretive financial and legal skill sets, I took it. Jones brought an extensive administrative, public relations and special events background. This position ended when she had to assist with the six year closure process of this facility due to the Base Realignment and Closure mandate.
While there she coordinated 10 Presidential visits, 6 major air shows, 5 golf tournaments as well as serving as the community liaison officer, emergency response media coordinator and command spokesperson. Additionally, she served as a Chief Administrator in the Navy Reserves for more than 18 years. She is a strong project manager and has brought innovative administrative ideas and organizational procedures with her to Tactix.
Assisting with the closure of the Naval Air Station was a daunting and stressful six year process. I was looking for a new challenge where I could apply my skills at a reputable growing company. Tactix is that and more; they are extremely well respected and their reputation as one of the best Tenant advisory firms in the Philadelphia area precedes them.
It's refreshing to be a part of a team of consummate professionals who work tirelessly for their clients. For the last several decades prior to joining Tactix in , Gary Lozoff was a practicing real estate and corporate transaction attorney in the Philadelphia region. Gary has handled legal aspects of all types of real estate matters, including commercial, industrial, residential, retail and hospitality asset acquisitions, financing, leasing, construction and operations, and condominium developments and conversions.
Gary has put particular emphasis in his professional practice on investment acquisitions, real estate development transactions, and user-based build-to-suit and other space leases.
I chose to join my other professional colleagues at Tactix to prove out three relatively simple, related theses:. Given his strong financial background, Kartik initially served as the firm's "go to" financial analyst, creating customized financial models for the firm's most complex transactions. Within a short period of time Kartik transitioned into full time brokerage. He has advised many clients in their commercial real estate needs in various industries, from high-profile law firms and pharmaceutical companies to legal, nonprofit, and public interest firms.
Prior to joining Tactix, Kartik was a financial associate for The Vanguard Group where he was responsible for daily mutual fund valuations including the Vanguard's Index , the largest mutual fund in the industry at the time.
During his tenure at Tactix, Kartik has had the privilege to work with the following companies among others:. Pennsylvania State University, B. Tactix is not about sales and revenue quotas.
It is about yielding outcomes that are in the best interest of our clients. We do it with a team of professionals who use their financial, business and legal acumen to strongly advocate for our clients.
Couple this with our collaborative team approach to all transactions and it was an easy decision to be part of the Tactix team.
Upon her move to the Philadelphia area, Trish quickly developed a sizable network and achieved measurable success as Director of Business Development for two Center City based architectural firms. Trish is a results-oriented, ethical marketing professional with a track record of success in helping professional service firms achieve growth.
A highly motivated, self starter, she has demonstrated business development, client service, presentation, and training skills. At Tactix, her focus is on increasing awareness of the firm, promoting technical staff expertise, and developing new business. With many years of direct experience and a proven track record of helping professional services firms achieve significant growth, I had numerous career opportunities available to me.
Tactix offered something different and compelling for my future. I chose Tactix because their reputation for excellence, ethical practices and commitment to client service, align perfectly with my personal and professional values. As such I can confidently and passionately introduce Tactix to prospective clients. Michael comes to Tactix armed with invaluable time spent within the financial industry. After four years working at a prominent Boston-based investment management firm, he returned home to the Philadelphia area to join Tactix.
With his financial knowledge and experience in sales, Michael brings a skill set that uniquely translates to relationship development, client retention, and lease negotiation.
When I started to consider transitioning into brokerage, I asked a lot of friends in the industry about Tactix. The response was always the same: I knew this was where I wanted to grow, and these were the people I wanted to learn from. Founded by lawyers, with a goal to eliminate all natural conflict of interests in an industry fraught with them simply made too much sense.
As soon as I joined the company, I knew I made the right decision. I really enjoy working with experienced professionals who have strong legal and financial backgrounds on high end transactions which enables me to get the best training and experience. Jennifer Stauffer joined Tactix with over 10 years of administrative experience.